Local Anesthetic Pharmaceutical Raw Material Articaine Hydrochloride CAS 23964-57-0

Articaine HCI Basic Info

 

Articaine HCI Descrption

Articaine HCl is a dental local anesthetic that contains an additional ester group that can be metabolized by esterases in the blood and tissues. Submucosal injection of 80 mg of 4% Articaine occurred after 10 to 15 minutes of maximum drug concentration. Articaine's elimination half-life is approximately 20 minutes. Compared with other local anesthetics, Articaine can spread better in soft and bone tissues. The concentration of Articaine in the groove after maxillary tooth extraction is 100 times higher than in systemic circulation.

Articaine HCI Application

Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine. from NCIt. A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE. from MeSH.
Articaine Hydrochloride is the hydrochloride salt form of articaine, an amide-type local anesthetic. Articaine hydrochloride reversibly blocks nerve impulse conduction by binding to specific membrane sodium ion channels thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. This results in a loss of sensation at the injection site. Articaine hydrochloride is used for relief of pain in minor operations.






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